Cartilage-protective effects of C-type natriuretic peptide over expression in K/BxN TCR arthritis model

نویسندگان

  • Hulya Bukulmez
  • Cynthia F Bartels
  • Kabita Nanda
  • Tariq M Haqqi
  • Jean F Welter
چکیده

Purpose The c-type natriuretic peptide (CNP) signaling pathway is known as a major contributor to skeletal growth in children. CNP is produced and secreted by both growth plate and joint chondrocytes, and has a paracrine regulatory effect on cartilage tissue. CNP increases matrix production by chondrocytes and promotes their proliferation. In this study, we investigated whether over-expression of CNP in chondrocytes would be protective of joint cartilage degradation during chronic inflammatory arthritis in vivo.

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عنوان ژورنال:

دوره 10  شماره 

صفحات  -

تاریخ انتشار 2012